Yahaya A. YABO

scRNA-seq reveals phenotypic heterogeneity and transcriptomic adaptation upon treatment in Glioblastoma Glioblastomas are heterogeneous and aggressive type of brain tumor, which hampers patient stratification and development of effective therapies. Glioblastomas create a dynamic ecosystem, where heterogeneous tumor cells interact with the tumor microenvironment (TME) to establish different niches. Upon tumor growth, Glioblastoma cells manifest remarkable … Continued


A metagenomic perspective of antimicrobial resistance in a One Health context The emergence and spread of antimicrobial resistance (AMR) is a global threat due to the inability to comprehensively treat bacterial infections. Resistant bacteria residing within human, animal and environmental reservoirs may spread from one to the other, at both local and global levels. Compounding … Continued


Novel NK activating multimeric immunotherapeutic complexes (NaMix) induce cytotoxic activity against HIV-1 infected cells in vitro and in vivo Combined Antiretroviral Therapy (cART) has transformed HIV-1 infection from a lethal disease into a chronic, manageable infectious disease. However, HIV-1 persists in viral reservoirs of latently infected CD4+ T cells containing integrated replication-competent viral DNA. cART … Continued


Emulating the gut-liver axis: Dissecting the microbiome’s effect on drug metabolism using multi-organ-on-chip models Introduction Over the past few years, several studies have shown that the gastrointestinal microbiome plays a key role in the processing of exogenous pharmaceutical compounds [1]. Additionally, previous work on the gut-liver axis has shown that the interplay between the intestinal … Continued


Dietary fibers differentially alter host immunity via gut microbial metabolism Although correlations between certain gut microbial taxa abundance and inflammation have paved the way to microbiome research in health and disease, the functionality of microbes through their metabolism in the context of host immunity remains to be elucidated. Given that dietary fibers are considered highly … Continued


TransSynW: A single-cell RNA-sequencing based web application to guide cell conversion experiments The goal of regenerative medicine is to create functional and faithful cell types that can replace damaged tissues. Although substantial progress has been achieved with novel reprogramming techniques, generating the cells of interest still poses problems. The advent of single cell RNA sequencing … Continued


Integrated genomics for the identification of novel factors controlling midbrain dopaminergic neuron differentiation Objective: In this project, we are studying the gene regulatory program underlying midbrain dopaminergic (mDAN) differentiation and identity for the identification of novel factors controlling this process. Background: Induced pluripotent stem cell (iPSC) technology allows us to reprogram human somatic cells into … Continued


Formate Promotes Invasion and Metastasis by Activating MMP2 excretion and Fatty Acid Synthesis Metabolic rewiring is essential to enable cancer cell proliferation, migration, invasion and metastasis. One important metabolic pathway that is often hijacked by cancer cells is the one-carbon cycle, in which the third carbon atom of serine is oxidized to formate. This metabolic … Continued


Translational states in NRAS-mutated melanoma preceding resistance to targeted therapy Despite the existence of an effective targeted therapy option for NRAS-mutant melanoma patients that involves combinatorial inhibition of MEK1/2 and CDK4/6, mechanisms of acquired resistance to these drugs are still unknown. Additional targeting of the PI3K-Akt-mTOR signaling pathway has been reported to be a promising … Continued


The rapid development of the (meta-)omics fields has produced an unprecedented amount of high-resolution and high-fidelity data. Through the use of these datasets we can infer the role of previously functionally unannotated proteins from single organisms and consortia. In this context, protein function annotation can be described as the identification of regions of interest (i.e., domains) in protein sequences and the assignment of biological functions. …