Metabolic re-wiring under glucose-limitation favours serine synthesis to support cancer cell survival Metabolism is an interlinked series of biochemical reactions that support biosynthesis, bioenergetics and redox balance on a cellular and a systemic level. One key metabolic pathway for proliferation is the one-carbon (1C) metabolism which is well documented to be upregulated in many tumours. … Continued
Roles of NEIL3 DNA glycosylase in glioblastoma telomere dynamics: From molecular insights to preclinical target validation There is no cure for glioblastoma (GBM), the most aggressive and lethal primary brain tumor. Cancer cells must activate mechanisms to maintain telomeres, the physical ends of our chromosomes, in order to acquire limitless replicative potential. Although targeting DNA … Continued
Characterization of tumor-associated microglia/macrophages in Glioblastoma and setting up of a large-scale drug screening for their functional reprogramming towards anti-tumoral cells Glioblastoma (GBM) is the most aggressive and malignant tumor that afflicts the central nervous system. GBM microenvironment is populated by different cell types, with tumor-associated microglia/macrophages (TAMs) representing the most abundant non-neoplastic cells. TAMs … Continued
The role of the microenvironment in colorectal cancer: a focus on cancer-associated fibroblasts Colorectal cancer (CRC) represents the second most common type of cancer in Luxembourg (GLOBACON Luxembourg 2018) and the second cause of cancer related deaths in 2020 (WHO). Patients classified in the Consensus Molecular Subtype 4 subgroup (CMS4), representing roughly 23% of all … Continued
scRNA-seq reveals phenotypic heterogeneity and transcriptomic adaptation upon treatment in Glioblastoma Glioblastomas are heterogeneous and aggressive type of brain tumor, which hampers patient stratification and development of effective therapies. Glioblastomas create a dynamic ecosystem, where heterogeneous tumor cells interact with the tumor microenvironment (TME) to establish different niches. Upon tumor growth, Glioblastoma cells manifest remarkable … Continued
Elucidation of the sulfur oxidation pathway in colorectal cancer cells and study of sulfur metabolism alterations in cancer tumorigenesis Globally, colorectal cancer (CRC) is the third leading cause of cancer-related death and the incidence is still increasing. Our gastrointestinal tract is home to hundreds of bacterial species, constituting the gut microbiome. Hydrogen sulfide (H2S) and … Continued
Identification of a small peptide targeting the Raf/Galectin interface to disrupt stabilised Ras signalling nanocluster The three genes, HRAS, NRAS and KRAS, are mutated in 19 % of cancers and developmental diseases called RASopathies. Despite the recently approved KRAS-G12C inhibitor Sotorasib, there are only very few treatment options for other RAS proteins.Active Ras is organized … Continued
NanoLuX: a network-wide Nanoluciferase-based platform to monitor activation, modulation and bias of classical and atypical chemokine receptors The activity of chemokine receptors is dependent on G proteins that, upon chemokine binding, trigger various intracellular signaling cascades, as well as on β-arrestins that, following receptor phosphorylation by GRK, orchestrate its desensitization, endocytosis and trafficking. In addition … Continued
Systematic reassessment reveals new pairings of the atypical chemokine receptors ACKR2, ACKR3 and ACKR4 with chemokines Atypical chemokine receptors (ACKRs) form a subfamily of four enigmatic chemokine receptors (ACKR1-4) unable to trigger G protein-dependent signalling in response to chemokines. However, they do play a crucial regulatory role in chemokine biology by capturing, scavenging or transporting … Continued
Novel NK activating multimeric immunotherapeutic complexes (NaMix) induce cytotoxic activity against HIV-1 infected cells in vitro and in vivo Combined Antiretroviral Therapy (cART) has transformed HIV-1 infection from a lethal disease into a chronic, manageable infectious disease. However, HIV-1 persists in viral reservoirs of latently infected CD4+ T cells containing integrated replication-competent viral DNA. cART … Continued