Title: K63-linked Ubiquitination in the Innate Immune Response Ubiquitination is a post-translational protein modification that critically regulates initiation,propagation and termination of the innate immune response. The ubiquitin-conjugating E2 enzyme 13 (Ubc13) catalyzes K63-linked polyubiquitin chains, which have non-proteolytic functions such asthe recruitment of binding partners. Ubc13-mediated ubiquitination plays an important role in NF-κBsignaling and is … Continued

Accurate long-read sequencing identified GBA variants as a major risk factor in the Luxembourgishcohort Objective: Assess the entire set of variants in the glucocerebrosidase (GBA) gene by long-readsequencing in the Luxembourg Parkinson’s study (LuxPARK) and characterize genotype-phenotypecorrelations of Parkinson’s disease (PD) patients carrying GBA variants.Background: Heterozygous variants in the GBA gene are an important risk … Continued

THE ROLE OF A PARKINSON’S DISEASE-ASSOCIATED RHOT1/MIRO1 VARIANT IN VITRO AND INVIVOObjective:The aim of this project is to identify disease-associated cellular phenotypes in Parkinson’s disease(PD) patients carrying RHOT1/Miro1 mutations and discover potential new targets to correctimpaired Miro1 function.Methods:We first assessed mitochondrial function in iPSC-derived neurons from a PD patient carrying theMiro1 R272Q mutation and the … Continued

Age- and sex-specific alterations in the midbrain of a Parkinson disease mouse model. Clinical diagnosis of Parkinson´s disease (PD) relies on the presence of motor symptoms, althoughnon-motor symptoms can manifest themselves already up to 20 years earlier. Dissecting molecularchanges occurring in the prodromal stages of the disease could facilitate earlier and more accuratediagnosis. It is … Continued

Accelerated dopaminergic differentiation precedes neuronal loss in a 3xSNCA midbrain organoidmodel of Parkinson’s diseaseParkinson’s disease (PD) is a complex, progressive neurodegenerative disease characterized by theloss of dopaminergic neurons in the substantia nigra pars compacta. While it is well established thatby the time PD patients are diagnosed, they have lost between 40-60% of their dopaminergicneurons in … Continued

RNAi-Mediated Loss of the NEIL3 DNA Glycosylase Leads to Deregulation of the TERRA LongNon-coding RNAs in Glioblastoma Cell Lines Glioblastoma (GBM) is the most aggressive type of brain tumor. Despite systemic treatment, GBMremains an incurable cancer with a median survival of only 15 months. Thus, urgent novel strategy isneeded to prevent treatment resistance in GBM. … Continued

Integrative analysis of gut microbiota composition, cecal gene expression as consequence ofdietary change, age, and genotypeAll animals’ intestinal tracts―from worms to fish to humans―are lined with a tremendous variety ofbacteria which can help the organism digest food and respond to environmental challenges, but which can also lead to disease when unbalanced. Therefore, it is essential … Continued

Overview of archaeal functions within the human gut microbiome using sequence- and structure-informed strategy for protein functional assignmentRoughly 40 years ago a separate and previously unknown branch of the Tree of Life – the Domain ofArchaea – was established. Archaea are remarkable not only in their ability to thrive in harshenvironments, but also in their … Continued

Early-life adversity leaves long-lasting taxonomic and metabolic imprints on the Oral Microbiome At birth, the microbiome is seeded by birth route and its composition evolves over the first 1000 daysof life. Tissue-specific microbiota are establish with distinctive abundance, diversity, and resilience.Key player for its development is the early exposome which also impacts the overall health … Continued

Drug candidates for repurposing through metabolic modelling of glioma show effectiveness inagreement with cell lines and xenografts data Gliomas are the most common type of malignant brain tumour, with glioblastoma having a mediansurvival of 15 months. Other than brain cancer, with tens of approved chemotherapies per cancertype as first line of treatment, only five are … Continued