Dietary Fiber, Gut Microbiota and Markers of Inflammation It is widely accepted that the gut microbiome plays a pivotal role in modulating inflammatory and immune responses of their host. In recent years, the host-microbiome interface has gained relevance in the understanding of the development of many non-communicable chronic conditions, including cardiovascular diseases, cancer, autoimmunity and … Continued
Maternal gut microbiome composition and diet modulate early life immune responses Early life is a critical period for the development of the newborn intestine, which undergoes microbiome colonization concomitant with the maturation of the mucus barrier and the immune system. In order to understanding of the role of the maternal microbiome on immune development in … Continued
A metagenomic perspective of antimicrobial resistance in a One Health context The emergence and spread of antimicrobial resistance (AMR) is a global threat due to the inability to comprehensively treat bacterial infections. Resistant bacteria residing within human, animal and environmental reservoirs may spread from one to the other, at both local and global levels. Compounding … Continued
Development of complement-activating immunotherapeutic complexes (CoMiX) targeting multidrug-resistant Pseudomonas aeruginosa Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen capable of causing a variety of life-threatening acute and chronic infections. P. aeruginosa evades complement-mediated cytotoxicity and phagocytosis by binding Factor H (FH), the main inhibitor of the alternative pathway. Factor H-related protein 4 (FHR4) was … Continued
Early life adversity marks the oral microbiome and immunophenotype: a holistic approach Introduction Microbial colonization begins at birth and develops over the first 36 months, establishing tissue-specific microbiota with unique abundance, diversity and robustness. Birthroute and early-life environment are key modulators of the microbiome. Furthermore, the early exposome influences the development of mental capabilities, immune … Continued
Alpha-synuclein-induced patholigies in brain and gut by curli and a fibre-deprived diet in a transgenic mouse model of Parkinson’s disease Parkinson’s disease (PD) is a complex, multi-factorial disease for which multiple mechanisms have been postulated contribute to its physiopathology. We hypothesize that PD can be triggered and driven by a combinatorial effect of reduced gut … Continued
Towards understanding the role of the microbiome in cancer Globally, colorectal cancer (CRC) is the third leading cause of cancer-related death. It has been suggested that the gut microbiome may play an important role in CRC initiation and progression, as there is evidence of a pathological imbalance in the gut microbiome in CRC patients. In … Continued
Emulating the gut-liver axis: Dissecting the microbiome’s effect on drug metabolism using multi-organ-on-chip models Introduction Over the past few years, several studies have shown that the gastrointestinal microbiome plays a key role in the processing of exogenous pharmaceutical compounds [1]. Additionally, previous work on the gut-liver axis has shown that the interplay between the intestinal … Continued
Dietary fibers differentially alter host immunity via gut microbial metabolism Although correlations between certain gut microbial taxa abundance and inflammation have paved the way to microbiome research in health and disease, the functionality of microbes through their metabolism in the context of host immunity remains to be elucidated. Given that dietary fibers are considered highly … Continued
Deciphering the role of colorectal-cancer associated bacteria in the fibroblast-tumor interaction Dysbiosis is an imbalance in the gut microbiome and has been associated with inflammation and cancer. Several microbial species, such as Fusobacterium nucleatum, are believed to be involved in the development of colorectal cancer (CRC). So far, most studies have only focused on the … Continued