Combinatory effect of proteinopathies on microglia responses in mixed-dementia hippocampus The hippocampus deterioration is at the centre of memory decline in the most common age- and dementia-related neurodegenerative diseases: Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB). However, its subregional atrophy pattern differs between both diseases, the CA1 subfield being more severely affected in … Continued
Lessons learned from COVID-19 medical imagining deep learning-based solutions: Towards clinically applicable models The breakthroughs of artificial intelligence on image analysis in the last years provide equal or even higher accuracy than specialists in the area, opening a new world of possibilities. The automatization of tasks conducted by experts enables not only time-saving analysis but … Continued
Selection of Drugs and Drug Combinations for SARS-CoV-2 Infected Lung through Metabolic Modeling The 2019 coronavirus disease (COVID-19) became a global pandemic with emerging variants that might escape the vaccine-induced immunity. Despite the global effort for mass vaccination with the newly developed vaccines, there is no effective antiviral drug except treatments for symptomatic therapy. Combining both whole genome sequences with our previous knowledge of biochemical reactions, metabolic networks … Continued
NanoLuX: a network-wide Nanoluciferase-based platform to monitor activation, modulation and bias of classical and atypical chemokine receptors The activity of chemokine receptors is dependent on G proteins that, upon chemokine binding, trigger various intracellular signaling cascades, as well as on β-arrestins that, following receptor phosphorylation by GRK, orchestrate its desensitization, endocytosis and trafficking. In addition … Continued
A metagenomic perspective of antimicrobial resistance in a One Health context The emergence and spread of antimicrobial resistance (AMR) is a global threat due to the inability to comprehensively treat bacterial infections. Resistant bacteria residing within human, animal and environmental reservoirs may spread from one to the other, at both local and global levels. Compounding … Continued
Early life adversity marks the oral microbiome and immunophenotype: a holistic approach Introduction Microbial colonization begins at birth and develops over the first 36 months, establishing tissue-specific microbiota with unique abundance, diversity and robustness. Birthroute and early-life environment are key modulators of the microbiome. Furthermore, the early exposome influences the development of mental capabilities, immune … Continued
Identification of cell-type and time point specific transcriptional regulators Processing and analysis of high-dimensional, complex omics data requires a variety of heterogenous software. Given the large volume of data produced, high performance computing is necessary to perform such analyses in time. Bioinformatics tools are developed individually and differ in file format as well as CPU … Continued
Circular RNAs to predict outcome after out-of-hospital cardiac arrest More than 400,000 cases of cardiac arrest (CA) occur each year in Europe. Among patients admitted to intensive care unit, the mortality rate averages 50%. Accurate prediction of outcomes would enable health care adaptation. Therefore, the discovery of new specific biomarkers could improve the prognosis of … Continued
Modelling COVID-19 dynamics Worldwide 223,914,634 confirmed cases and 4,618,234 dead people have been identified to be infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by 11th September 2021. COVID-19 is a new strain of coronavirus SARS-COV-2 (severe acute respiratory syndrome coronavirus 2). The first outbreak was reported in December 2019 in Wuhan, China. COVID-19 … Continued
Allergy burden in Luxembourg: a population-based, cross-sectional health survey paralleled by component-resolved-IgE-diagnosis INTRODUCTION: Allergy is the most common chronic health condition in Europe. The European Health Examination Survey (EHES) study is a population-based, cross-sectional survey on baseline characteristics of the general health status representative for adults. The aim of this study was to establish a … Continued