Dietary Fiber, Gut Microbiota and Markers of Inflammation It is widely accepted that the gut microbiome plays a pivotal role in modulating inflammatory and immune responses of their host. In recent years, the host-microbiome interface has gained relevance in the understanding of the development of many non-communicable chronic conditions, including cardiovascular diseases, cancer, autoimmunity and … Continued


Maternal gut microbiome composition and diet modulate early life immune responses Early life is a critical period for the development of the newborn intestine, which undergoes microbiome colonization concomitant with the maturation of the mucus barrier and the immune system. In order to understanding of the role of the maternal microbiome on immune development in … Continued


Microglia programs under PARK7/DJ-1 deficiency, a genetic cause of Parkinson’s disease, in a DJ-1 mouse model and human induced pluripotent stem cell-derived microglia It is increasingly evident that dysregulated microglia are implicated in neurodegenerative diseases, such as Parkinson’s disease (PD). The majority of PD cases are idiopathic but in around 10% of patients suffering from … Continued


Metabolic re-wiring under glucose-limitation favours serine synthesis to support cancer cell survival Metabolism is an interlinked series of biochemical reactions that support biosynthesis, bioenergetics and redox balance on a cellular and a systemic level. One key metabolic pathway for proliferation is the one-carbon (1C) metabolism which is well documented to be upregulated in many tumours. … Continued


Roles of NEIL3 DNA glycosylase in glioblastoma telomere dynamics: From molecular insights to preclinical target validation There is no cure for glioblastoma (GBM), the most aggressive and lethal primary brain tumor. Cancer cells must activate mechanisms to maintain telomeres, the physical ends of our chromosomes, in order to acquire limitless replicative potential. Although targeting DNA … Continued


Characterization of tumor-associated microglia/macrophages in Glioblastoma and setting up of a large-scale drug screening for their functional reprogramming towards anti-tumoral cells Glioblastoma (GBM) is the most aggressive and malignant tumor that afflicts the central nervous system. GBM microenvironment is populated by different cell types, with tumor-associated microglia/macrophages (TAMs) representing the most abundant non-neoplastic cells. TAMs … Continued

Anne-Marie HANFF

Development of a new Functional Mobility Composite Score in Parkinson’s disease: Sample characteristics of the NCER-PD cohort and exploratory analyses on internal consistency and stability OBJECTIVES Describe the characteristics of people with typical Parkinson’s disease (PD) participating in the NCER cohort. Explore the internal consistency and stability of the Functional Mobility Composite Score (FMCS). BACKGROUND … Continued


Exploring the retrograde procedural memory in Parkinson’s disease in the Luxembourg Parkinson’s Study Objective: The present project focused on developing a neuropsychological tool for the evaluation of the retrograde procedural memory in Parkinson’s disease. Background: Many daily life activities such as playing the piano, driving a manual car or tying one’s shoes rely on the … Continued

Rubens BEGAJ

The role of the microenvironment in colorectal cancer: a focus on cancer-associated fibroblasts Colorectal cancer (CRC) represents the second most common type of cancer in Luxembourg (GLOBACON Luxembourg 2018) and the second cause of cancer related deaths in 2020 (WHO). Patients classified in the Consensus Molecular Subtype 4 subgroup (CMS4), representing roughly 23% of all … Continued

Yahaya A. YABO

scRNA-seq reveals phenotypic heterogeneity and transcriptomic adaptation upon treatment in Glioblastoma Glioblastomas are heterogeneous and aggressive type of brain tumor, which hampers patient stratification and development of effective therapies. Glioblastomas create a dynamic ecosystem, where heterogeneous tumor cells interact with the tumor microenvironment (TME) to establish different niches. Upon tumor growth, Glioblastoma cells manifest remarkable … Continued