Anne-Marie HANFF

Development of a new Functional Mobility Composite Score in Parkinson’s disease: Sample characteristics of the NCER-PD cohort and exploratory analyses on internal consistency and stability
OBJECTIVES
Describe the characteristics of people with typical Parkinson’s disease (PD) participating in the NCER cohort.
Explore the internal consistency and stability of the Functional Mobility Composite Score (FMCS).
BACKGROUND
No patient-reported assessment captures the concept of functional mobility in people with PD according to its definition. We developed a patient-reported FMCS including components of two existing, validated, and translated patient-reported assessments: Subscale Mobility of the PDQ-39 Health-Related Quality of Life Questionnaire and the MDS-UPDRS II questionnaire about motor aspects of experiences of daily living.
METHODS AND RESULTS
Tables and figures can be accessed via the QR-code. Tables 1 and 2 summarize the baseline characteristics and profiles of people with PD in the 1st and the 3rd tertile of the FMCS. Consequently, we identified potential determinants contributing to differences between high and low FMCS.
29.4% – 32.8% of people with PD showed no clinically significant deterioration of the components of the FMCS from t1 to t4. Spearman’s rho reveales strong correlations of 0.74 and 0.87 (p < 0.001) of the FMCS at all time points. The correlation matrix indicates significant multicorrelation of the PDQ-39 subscale mobility items, while this is only the case for mobility-related items of the MDS-UPDRS II i.e. getting up, walking, freezing. Satisfying internal consistency (Cronbachs’ α = 0.95 at each of t1 to t4).
CONCLUSIONS
Determinants of differences between people with PD with high and low functional mobility were identified. The results imply FMCS captures small (clinically significant) changes over time with satisfying internal consistency. In a next step the new FMCS will be validated.

 

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