Jessica KARTA

Deciphering the role of colorectal-cancer associated bacteria in the fibroblast-tumor interaction
Dysbiosis is an imbalance in the gut microbiome and has been associated with inflammation and cancer. Several microbial species, such as Fusobacterium nucleatum, are believed to be involved in the development of colorectal cancer (CRC). So far, most studies have only focused on the interaction between this type of bacterium and tumor cells. However, the tumor microenvironment (TME) is a highly heterogeneous system of different cell types. The relationship between cancer-associated fibroblasts (CAFs), which can be considered to be one of the most vital players in the TME, and CRC-associated bacteria remains unknown. Thus, my PhD aims to decipher the interactions taking place between F. nucleatum and CAFs and their subsequent effects on colonic tumor progression.

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